Supreme Rejuvenation
WELCOME TO SUPREME REJUVENATION
ELEVATING HEALTHCARE THROUGH SCIENTIFIC RESEARCH AND INNOVATION
At Supreme Rejuvenation, we are committed to exploring the potential applications of stem cell-derived exosomes through rigorous scientific research. The product line is developed with the aim of enhancing physical and mental performance, increasing energy levels, and promoting overall vitality. These products are intended strictly for research and investigational purposes and are not approved for general medical use.
Our Vision: Cultivating Bio-Wellness for Holistic Well-Being
Our overarching goal is to foster a culture of bio-wellness, seeking harmony within the mind, body, and cellular processes. Through comprehensive education and research, we aim to kindle a passion for optimizing bodily functions, improving health, and unlocking an individual’s fullest potential.
Core Offerings: MSC Exosome Research Product Line
Central to the research initiatives is the MSC exosome product line. These exosomes are intricately designed for investigational studies to explore their potential in enhancing the body’s performance, enabling individuals to achieve health and life goals with unprecedented efficacy.
About Us
THE Commitment to Excellence: Ensuring Regulatory Compliance and Quality Assurance
- Regulatory Adherence: Regenerative medicine products are provided in compliance with FDA 351(a) drug regulations, ensuring the highest level of regulatory compliance. All products are intended soy for research and investigational purposes.
- Comprehensive Testing: Each product under goes rigorous third-party testing, including Endotoxin and Mycoplasma Reports, Sterility Reports, Nanoparticle Tracking Analysis (N.T.A.), and Proteomics Assays to assess relevant proteins.
- Product Specifications: Regenerative medicine products are designed to target inflammation and repair damaged tissues. They are intended for use in studies related to hair growth and wound care to addressing Traumatic Brain Injury, joint and ligament repair, Botox alternatives, IV infusions, various other conditions. Each batch is NTA and CD81 Protein Tested, ensuring quantity of 28 billion units per millimeter/cubic centimeter (mL/cc).
Important Regulatory Notice:
As of March 2025, the U.S. Food and Drug Administration (FDA) has not approved any exosome products for general medical use. Exosome products intended for the treatment of human diseases and conditions are regulated as drugs under the Federal Food, Drug, and Cosmetic Act and as biological products under the Public Health Service Act. These products require FDA approval before they can be marketed for such uses. Supreme Rejuvenation’s products are intended exclusively for research and investigational purposes and are not approved for general medical use.
Join in Advancing Scientific Understanding
Researchers and healthcare professionals are invited to collaborate in the pursuit of scientific knowledge and the exploration of potential therapeutic applications of stem cell-derived exosomes. Together, progress can be made in the advancement of regenerative medicine.
Supreme Rejuvenation
24 Hr Delivery
3rd Party Virology Test
TOPICAL EXOSOME GEL DERIVED FROM THE HUMAN UMBILICAL CORD
Experience the extraordinary power of the patented Exosome technology in the beneficial Topical Gel. The unique patented technology not only harnesses the potential of Exosomes but also extends the stability and shelf life of the product, facilitating convenient application for research purposes.
Exosomes are nano-sized vesicles secreted by stem cells, encapsulating growth factors, cytokines, and other bioactive molecules with potential regenerative properties. Their unique structure enables the transfer of these components to recipient cells, making them a focal point of current research in regenerative medicine.
Advancing Research in Skincare and Regenerative Therapy
This innovative technology represents a significant advancement in the exploration of skincare and regenerative therapy. The Topical Gel serves as a testament to scientific progress, offering researchers a tool to study its effects on skin health and overall well-being.
- Introducing Regenerative Aesthetics
- 15ml-100 Billion Exosomes
- 30 ml-200 Billion Exosomes
Human Umbilical Cord Stem Cell Derived Exosome
Sterile Saline 100 Billion Exosomes per 5cc
The sterile saline serum harnesses the remarkable potential of exosomes, tiny vesicles secreted by stem cells. These exosomes possess a unique structure that enables them to fuse with other cells within the body, facilitating the release of their potent contents. The content include cytokines, growth factors, and mRNA, which act as signaling molecules, triggering a cascade of regenerative processes within the target cells. This intricate mechanism essentially empowers the cells to heal themselves.
What sets exosomes apart from stem cells is their distinctive characteristics. Exosomes do not replicate, contain DNA, or induce an immune response. Consequently, the serum is a safer alternative when compared to stem cell therapies. Importantly, exosome products are inherently cell-free and contain no live cells by definition, ensuring safety and efficacy.
For extended preservation, storage at cryo-freezer (-80°C) temperatures, is recommended, which can prolong the shelf life up to 18 months.
SCAR REJUVENATION AND WOUND CURATION
At Supreme Rejuvenation, we are committed to exploring innovative approaches to skin health and wound care. The exosome-based technology is designed to support the natural healing process by influencing cellular communication and tissue dynamics
Mesenchymal stem cell (MSC)-derived exosomes are extracellular vesicles that play a role in cellular signaling. Research suggests that these exosomes may influence collagen organization and fibroblast activity, which are key factors in skin repair. By facilitating an optimal environment for tissue remodeling, MSC exosomes may contribute to a more refined appearance of healed skin.
MSC-derived exosomes are believed to support tissue health through intercellular communication. These vesicles contain bioactive molecules that may promote cellular responses associated with tissue repair and regeneration. While ongoing studies continue to investigate their full potential, exosome-based applications represent an exciting area of scientific exploration in regenerative skincare.
Facial Firming Serum with Exosomes
100 Billion Exosomes/15ml
200 Billion Exosomes /30ml
Aloe Leaf Juice, Alcohol, DMAE bitartrate, Jojoba Seed Oil, Emulsifying Wax, Glycerin, MSM, Rooibos Leaf Extract, Hyaluronic Acid, Green Tea Leaf Extract, White Tea Leaf Extract, White Willow Bark Extract, Vitamin E, Sunflower Seed Oil, Vitamin B3, Xanthan Gum, Human Umbilical
Cord Mesenchymal Stem Cell Derived Exosomes, Cytokines and Growth Factors.
Vitamin Serum with Exosomes
100 Billion Exosomes/15ml
200 Billion Exosomes /30ml
Organic Aloe Leaf Juice (Aloe barbadensis), Glycerin, Vitamin B3 (Niacinamide), Emulsifying Wax (Cetyl Alcohol, Stearyl Alcohol, Polysorbate 60), Avocado Fruit Oil (Persea gratissima), Hyaluronic Acid, Vitamin E (Tocopherol), Sunflower Seed Oil (Helianthus Annuus), Organic Neem Seed Oil (Melia azadirachta), Organic Rosemary Leaf Extract (Rosmarinus officinalis), Organic Sunflower Seed Oil (Helianthus annuus), Xanthan Gum, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes, Cytokines and Growth Factors.
What Are Exosomes
Exosomes, these remarkable entities, are intricately involved in cellular communication and regenerative processes. They are minute vesicles originating from various cell types, including stem cells. These tiny packages are bestowed with an extraordinary capacity to contain and transport a diverse range of bioactive molecules.
Within the confines of exosomes lie substantial quantities of growth factors, cytokines, and an array of other bioactive substances. It’s this rich molecular payload that imparts upon exosomes their unique regenerative potential. What truly sets exosomes apart is their exceptional structure that enables them to transfer these bioactive cargo to neighboring cells.
This transfer of regenerative signals is pivotal in the world of cellular health. Exosomes act as nature’s messengers, facilitating intercellular communication. When they fuse with target cells, they deliver their payload, thereby kickstarting processes that promote tissue repair, regeneration, and growth.
How They Work
Stem cell-derived exosomes are the unsung heroes of regenerative medicine, orchestrating the body’s healing processes in a fascinating way. Here’s a closer look at how they work:
Identification of Injury: When tissue is injured, it releases chemical markers indicating the extent of damage. These markers act as distress signals.
Stem Cell Response: Stem cells, with their remarkable sensing abilities, pick up on these signals. They “know” that specific repair components are needed.
Customized Healing Components: Stem cells swing into action, producing the precise components required for healing the injured tissue. This includes growth factors, cytokines, and more.
Packaging in Exosomes: These components are meticulously packaged into tiny vesicles known as exosomes. Think of exosomes as tiny delivery vehicles loaded with healing cargo.
Guided Delivery: Exosomes are released by stem cells and migrate to the site of the injured tissue. They’re like GPS-guided messengers, pinpointing the area that needs repair.
Healing Handover: Once at the injury site, exosomes attach themselves. Then comes the magic moment when they release their healing contents directly to the injured tissue.
The result: Remarkable tissue rejuvenation and regeneration. Stem cell-derived exosomes have shown incredible efficacy in various studies, from peripheral nerve damage and traumatic brain injury to wound healing, bone fusion, and more. They possess anti-inflammatory properties and play vital roles in skin, cartilage, and bone regeneration, making them versatile assets in regenerative medicine.
Despite their proven effects, it’s worth noting that, as of now, there are no FDA-approved exosome products available in the United States. Researchers continue to explore their potential and safety in clinical applications.
This is how stem cell-derived exosomes work their magic, offering promising avenues for cutting-edge therapies and tissue repair.
Why Use Umbilical Cord Msc Derived Exosomes
Understanding the complexities and limitations of using live stem cells in medical treatments is crucial. Here’s an improved explanation:
Regulatory Complexity: Live stem cells carry significant medical risks, leading to stringent regulation. Presently, their lawful use is restricted to two scenarios: when derived from the patient’s own body or when they remain unaltered for tissue transplantation. However, these methods have inherent drawbacks beyond health risks.
Tissue Specificity: Tissues used for transplantation can only be applied to similar tissues. For instance, placental membranes are limited to skin-type tissues, restricting their versatility.
Aging and Diminished Efficacy: Self-derived stem cells are prone to age-related degradation. Typically, by the age of 40, the efficacy of a person’s stem cells starts declining. This decline is even more pronounced in patients around 60, precisely the age when many require stem cell therapies.
Supreme Rejuvenation is committed to supporting scientific research and innovation in regenerative studies. Exosome-based formulations derived from carefully screened human umbilical cord sources undergo extensive quality testing, including third-party virology assessments, to ensure consistency and safety.
Exosomes available for research and investigational use are registered under the applicable regulatory framework. While ongoing studies continue to explore their potential applications, exosome research remains an evolving field with promising implications across various scientific disciplines.
Research results
At Supreme Rejuvenation, we are dedicated to supporting research and innovation in regenerative science. The exosome-based formulations are derived from carefully screened human umbilical cord sources and undergo rigorous quality testing, including third-party virology assessments, to ensure safety and consistency.
These exosomes are registered for research and investigational use under the applicable regulatory framework. While ongoing studies explore their potential applications, exosome research is an evolving field with promising implications across various areas of scientific inquiry.
Emerging research suggests that exosomes may play a role in cellular signaling, tissue dynamics, and physiological processes. Studies are investigating their potential influence on skin health, tissue remodeling, and other areas of regenerative science. Additionally, ongoing research continues to examine how exosomes may contribute to broader applications in fields such as cardiology, aesthetics, and neurological research.
It is important to note that exosome-based products are currently intended for research purposes and are not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Supreme Rejuvenation is committed to advancing responsible scientific exploration while adhering to regulatory guidelines.
In the field of aesthetics, the exosomes have been shown to improve skin texture, reduce wrinkles, and stimulate hair growth. In a study conducted by Dr. Berman, the exosomes were found to stimulate hair growth in patients with androgenetic alopecia.
Furthermore, the exosomes have been shown to have neuro-protective effects and can promote nerve regeneration in conditions such as optic nerve damage and glaucoma. Studies have also shown that the exosomes can improve symptoms in patients with COVID-19 long-haulers and dementia.
In orthopedics, the exosomes have been shown to reduce inflammation and promote cartilage regeneration, making them effective in treating arthritis and other joint-related conditions. The exosomes have also been shown to improve outcomes in spinal cord injuries.
At Supreme Rejuvenation, a Texas-based distribution company, we are committed to distributing exosome products that are the culmination of extensive research and development. These products are designed to meet rigorous quality standards, aiming to support advancements in exosome research.
For more detailed information on the studies and research supporting exosome technology, please refer to the following resources:
Future Products
These are the following future product lines and are looking forward to getting appropriate FDA clearances to allow sales and distribution of these products soon.
ADDITIVE:
For FDA Devices/saline.
EAR DROPS:
Dropper bottle with calibrated dropper
EYE DROP:
Case of 20x 5ml eye droppers
CLINICAL INHALATION:
Dropper bottle for use with a nebulizer
TOPICAL (CREAM/LOTION/SERUM):
Packaging to be determined
HOME USE INHALATION:
Pressurized Inhaler
WOUND CARE:
Hydro Gel in a medical spray, possibly coupled with a bandage S
NASAL SPRAY:
Spray Bottle For Nasal Inhalation
DERMATOLOGY/AESTHETIC FOR POST-SKIN TREATMENT:
Spray Specialized applicator
VAGINAL USE:
Utilizing Hydro Gel