Supreme Rejuvenation

WELCOME TO SUPREME REJUVENATION
ELEVATING HEALTHCARE THROUGH SCIENTIFIC RESEARCH AND INNOVATION

At Supreme Rejuvenation, we support the responsible exploration of exosome-based formulations derived from human umbilical cord mesenchymal stem cells. Our focus is on providing high-quality materials intended strictly for research and investigational purposes, consistent with applicable FDA guidelines.

Our Vision: Supporting Scientific Discovery in Cellular Discovery

We aim to foster collaboration within the scientific and medical research communities by supplying exosome-based materials for labratory use. Our goal is to encourage safe, ethical investigation into cellular signaling properties of exosomes and their potential role in regenerative biology.

Core Offerings: Research Product Portfolio

Our offerings include research-use-only exosome formulations derived from rigorously screened human umbilical cord sources. These products are manufactured under controlled conditions and are subject to third party testing including sterility and particle analysis.

Important Regulatory Notice

As of 2025, the U.S. Food and Drug Administration (FDA) has not approved any exosome products for clinical diagnosis, treatment, cure, or prevention of any disease or condition. All products provided by Supreme Rejuvenation LLC are intended exclusively for non-clinical, investigational and labratory based research use.

About Us

THE Commitment to Excellence: Ensuring Regulatory Compliance and Quality Assurance

Regulatory Alignment: Supreme Rejuvenation supports scientific research by supplying exosome materials classified as biological substances for research use only. We do not market or distribute these materials for medical or therapeutic use.

Testing Protocols: Every batch undergoes extensive third party testing, including sterility, endotoxin levels, nano tracking analysis (NTA), and protien profiling.

Product Use Statement: These products are not intended for use in humans or animals for therapeutic purposes.

Research Applications

Supreme Rejuvenation encourages the exploration of how exosomes can contribute to cellular communication in controlled research environments.

DISCLAIMER: Supreme Rejuvenation does not claim efficacy for any exosome formulation. References to studies or potential applications are provided for informational purposes only and should not be interpreted as product claims.

24 Hr Delivery

3rd Party Virology Test

TOPICAL EXOSOME GEL DERIVED FROM THE HUMAN UMBILICAL CORD

Experience the extraordinary power of the patented Exosome technology in the beneficial Topical Gel. The unique patented technology not only harnesses the potential of Exosomes but also extends the stability and shelf life of the product, facilitating convenient application for research purposes.

Exosomes are nano-sized vesicles secreted by stem cells, encapsulating growth factors, cytokines, and other bioactive molecules with potential regenerative properties. Their unique structure enables the transfer of these components to recipient cells, making them a focal point of current research in regenerative medicine.

Advancing Research in Skincare and Regenerative Therapy

This innovative technology represents a significant advancement in the exploration of skincare and regenerative therapy. The Topical Gel serves as a testament to scientific progress, offering researchers a tool to study its effects on skin health and overall well-being.

Human Umbilical Cord Stem Cell Derived Exosome

Sterile Saline 100 Billion Exosomes per 5cc

The sterile saline serum harnesses the remarkable potential of exosomes, tiny vesicles secreted by stem cells. These exosomes possess a unique structure that enables them to fuse with other cells within the body, facilitating the release of their potent contents. The content include cytokines, growth factors, and mRNA, which act as signaling molecules, triggering a cascade of regenerative processes within the target cells. This intricate mechanism essentially empowers the cells to heal themselves.

What sets exosomes apart from stem cells is their distinctive characteristics. Exosomes do not replicate, contain DNA, or induce an immune response. Consequently, the serum is a safer alternative when compared to stem cell therapies. Importantly, exosome products are inherently cell-free and contain no live cells by definition, ensuring safety and efficacy.

For extended preservation, storage at cryo-freezer (-80°C) temperatures, is recommended, which can prolong the shelf life up to 18 months.

SCAR REJUVENATION AND WOUND CURATION

At Supreme Rejuvenation, we are committed to exploring innovative approaches to skin health and wound care. The exosome-based technology is designed to support the natural healing process by influencing cellular communication and tissue dynamics

Mesenchymal stem cell (MSC)-derived exosomes are extracellular vesicles that play a role in cellular signaling. Research suggests that these exosomes may influence collagen organization and fibroblast activity, which are key factors in skin repair. By facilitating an optimal environment for tissue remodeling, MSC exosomes may contribute to a more refined appearance of healed skin.

MSC-derived exosomes are believed to support tissue health through intercellular communication. These vesicles contain bioactive molecules that may promote cellular responses associated with tissue repair and regeneration. While ongoing studies continue to investigate their full potential, exosome-based applications represent an exciting area of scientific exploration in regenerative skincare.

Facial Firming Serum with Exosomes

100 Billion Exosomes/15ml
200 Billion Exosomes /30ml

Aloe Leaf Juice, Alcohol, DMAE bitartrate, Jojoba Seed Oil, Emulsifying Wax, Glycerin, MSM, Rooibos Leaf Extract, Hyaluronic Acid, Green Tea Leaf Extract, White Tea Leaf Extract, White Willow Bark Extract, Vitamin E, Sunflower Seed Oil, Vitamin B3, Xanthan Gum, Human Umbilical
Cord Mesenchymal Stem Cell Derived Exosomes, Cytokines and Growth Factors.

Vitamin Serum with Exosomes

100 Billion Exosomes/15ml
200 Billion Exosomes /30ml

Organic Aloe Leaf Juice (Aloe barbadensis), Glycerin, Vitamin B3 (Niacinamide), Emulsifying Wax (Cetyl Alcohol, Stearyl Alcohol, Polysorbate 60), Avocado Fruit Oil (Persea gratissima), Hyaluronic Acid, Vitamin E (Tocopherol), Sunflower Seed Oil (Helianthus Annuus), Organic Neem Seed Oil (Melia azadirachta), Organic Rosemary Leaf Extract (Rosmarinus officinalis), Organic Sunflower Seed Oil (Helianthus annuus), Xanthan Gum, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Human Umbilical Cord Mesenchymal Stem Cell Derived Exosomes, Cytokines and Growth Factors.

What Are Exosomes

Exosomes, these remarkable entities, are intricately involved in cellular communication and regenerative processes. They are minute vesicles originating from various cell types, including stem cells. These tiny packages are bestowed with an extraordinary capacity to contain and transport a diverse range of bioactive molecules.

Within the confines of exosomes lie substantial quantities of growth factors, cytokines, and an array of other bioactive substances. It’s this rich molecular payload that imparts upon exosomes their unique regenerative potential. What truly sets exosomes apart is their exceptional structure that enables them to transfer these bioactive cargo to neighboring cells.

This transfer of regenerative signals is pivotal in the world of cellular health. Exosomes act as nature’s messengers, facilitating intercellular communication. When they fuse with target cells, they deliver their payload, thereby kickstarting processes that promote tissue repair, regeneration, and growth.

How They Work

Stem cell-derived exosomes are the unsung heroes of regenerative medicine, orchestrating the body’s healing processes in a fascinating way. Here’s a closer look at how they work:

Identification of Injury: When tissue is injured, it releases chemical markers indicating the extent of damage. These markers act as distress signals.
Stem Cell Response: Stem cells, with their remarkable sensing abilities, pick up on these signals. They “know” that specific repair components are needed.
Customized Healing Components: Stem cells swing into action, producing the precise components required for healing the injured tissue. This includes growth factors, cytokines, and more.
Packaging in Exosomes: These components are meticulously packaged into tiny vesicles known as exosomes. Think of exosomes as tiny delivery vehicles loaded with healing cargo.
Guided Delivery: Exosomes are released by stem cells and migrate to the site of the injured tissue. They’re like GPS-guided messengers, pinpointing the area that needs repair.
Healing Handover: Once at the injury site, exosomes attach themselves. Then comes the magic moment when they release their healing contents directly to the injured tissue.

The result: Remarkable tissue rejuvenation and regeneration. Stem cell-derived exosomes have shown incredible efficacy in various studies, from peripheral nerve damage and traumatic brain injury to wound healing, bone fusion, and more. They possess anti-inflammatory properties and play vital roles in skin, cartilage, and bone regeneration, making them versatile assets in regenerative medicine.

Despite their proven effects, it’s worth noting that, as of now, there are no FDA-approved exosome products available in the United States. Researchers continue to explore their potential and safety in clinical applications.

This is how stem cell-derived exosomes work their magic, offering promising avenues for cutting-edge therapies and tissue repair.

Why Use Umbilical Cord Msc Derived Exosomes

Understanding the complexities and limitations of using live stem cells in medical treatments is crucial. Here’s an improved explanation:

Regulatory Complexity: Live stem cells carry significant medical risks, leading to stringent regulation. Presently, their lawful use is restricted to two scenarios: when derived from the patient’s own body or when they remain unaltered for tissue transplantation. However, these methods have inherent drawbacks beyond health risks.

Tissue Specificity: Tissues used for transplantation can only be applied to similar tissues. For instance, placental membranes are limited to skin-type tissues, restricting their versatility.
Aging and Diminished Efficacy: Self-derived stem cells are prone to age-related degradation. Typically, by the age of 40, the efficacy of a person’s stem cells starts declining. This decline is even more pronounced in patients around 60, precisely the age when many require stem cell therapies.

Supreme Rejuvenation is committed to supporting scientific research and innovation in regenerative studies. Exosome-based formulations derived from carefully screened human umbilical cord sources undergo extensive quality testing, including third-party virology assessments, to ensure consistency and safety.

Exosomes available for research and investigational use are registered under the applicable regulatory framework. While ongoing studies continue to explore their potential applications, exosome research remains an evolving field with promising implications across various scientific disciplines.

Research results

At Supreme Rejuvenation, we are dedicated to supporting research and innovation in regenerative science. The exosome-based formulations are derived from carefully screened human umbilical cord sources and undergo rigorous quality testing, including third-party virology assessments, to ensure safety and consistency.

These exosomes are registered for research and investigational use under the applicable regulatory framework. While ongoing studies explore their potential applications, exosome research is an evolving field with promising implications across various areas of scientific inquiry.

Emerging research suggests that exosomes may play a role in cellular signaling, tissue dynamics, and physiological processes. Studies are investigating their potential influence on skin health, tissue remodeling, and other areas of regenerative science. Additionally, ongoing research continues to examine how exosomes may contribute to broader applications in fields such as cardiology, aesthetics, and neurological research.

It is important to note that exosome-based products are currently intended for research purposes and are not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Supreme Rejuvenation is committed to advancing responsible scientific exploration while adhering to regulatory guidelines.

In the field of aesthetics, the exosomes have been shown to improve skin texture, reduce wrinkles, and stimulate hair growth. In a study conducted by Dr. Berman, the exosomes were found to stimulate hair growth in patients with androgenetic alopecia.

Furthermore, the exosomes have been shown to have neuro-protective effects and can promote nerve regeneration in conditions such as optic nerve damage and glaucoma. Studies have also shown that the exosomes can improve symptoms in patients with COVID-19 long-haulers and dementia.

In orthopedics, the exosomes have been shown to reduce inflammation and promote cartilage regeneration, making them effective in treating arthritis and other joint-related conditions. The exosomes have also been shown to improve outcomes in spinal cord injuries.

At Supreme Rejuvenation, a Texas-based distribution company, we are committed to distributing exosome products that are the culmination of extensive research and development. These products are designed to meet rigorous quality standards, aiming to support advancements in exosome research.

For more detailed information on the studies and research supporting exosome technology, please refer to the following resources: